TTX 334Dx Endo

 

TIME TO CONQUER 

Mission: Improve the quality of life for #1in10 reproductive aged women with endometriosis

Photo by Denys Nevozhai

 

Goal: Develop a non-invasive, accurate and reliable diagnostic for endometriosis

Problem:  Lack of reliable non-invasive diagnostic method to accurately diagnose endometriosis leads to years of emotional and physical suffering and reduced quality of life.

How: Harness the pro-fibrotic nature of endometriosis and oxidative stress biomarkers to advance precision medicine for diagnosis and ultimately treatment for endometriosis. A collaboration and co-development project with EndoDiag

Disease Background

Endometriosis affects 6-11% of premenopausal women, causing pain, infertility, reduced quality of life and billions of $70 Billion in 2016 (GlobalData 2018) in health care related costs annually. Currently laparoscopic surgery is the only means for providing a definitive diagnosis of endometriosis and most patients struggle to find an effective treatment modality to relieve symptoms. While numerous studies have investigated non-invasive biomarkers for diagnosing endometriosis and predict prognosis and appropriate treatment, none have shown sufficient performance to be translated into clinical use.

What does this mean in context?

  • At present accurate diagnosis is invasive-laparoscopic surgery
  • Endometriosis is the number 1 cause of infertility in the US
  • Prolonged diagnosis cycles rob women of valuable child-bearing years
  • A woman with a sister or mother with endometriosis is six times more likely to develop endometriosis than a woman without this family history
  • Over 400,000 hysterectomies are attributed to advanced stage endometriosis

Work Cited

REFERENCES

1.           Simoens S, Dunselman G, Dirksen C, Hummelshoj L, Bokor A, Brandes I, et al. The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres. Hum Reprod. 2012;27(5):1292-9. Epub 2012/03/14. doi: 10.1093/humrep/des073. PubMed PMID: 22422778.

2.           Burghaus S, Klingsiek P, Fasching PA, Engel A, Häberle L, Strissel PL, et al. Risk Factors for Endometriosis in a German Case-Control Study. Geburtshilfe Frauenheilkd. 2011;71(12):1073-9. doi: 10.1055/s-0031-1280436. PubMed PMID: 25253901; PubMed Central PMCID: PMCPMC4166917.

3.           Burghaus S, Häberle L, Schrauder MG, Heusinger K, Thiel FC, Hein A, et al. Endometriosis as a risk factor for ovarian or endometrial cancer - results of a hospital-based case-control study. BMC Cancer. 2015;15:751. Epub 2015/10/21. doi: 10.1186/s12885-015-1821-9. PubMed PMID: 26487094; PubMed Central PMCID: PMCPMC4618513.

4.           Nnoaham KE, Webster P, Kumbang J, Kennedy SH, Zondervan KT. Is early age at menarche a risk factor for endometriosis? A systematic review and meta-analysis of case-control studies. Fertil Steril. 2012;98(3):702-12.e6. Epub 2012/06/22. doi: 10.1016/j.fertnstert.2012.05.035. PubMed PMID: 22728052; PubMed Central PMCID: PMCPMC3502866.

5.           Alpay Z, Saed GM, Diamond MP. Female infertility and free radicals: potential role in adhesions and endometriosis. J Soc Gynecol Investig. 2006;13(6):390-8. Epub 2006/07/26. doi: 10.1016/j.jsgi.2006.05.002. PubMed PMID: 16872846.

6.           Ganieva U, Nakamura T, Osuka S, Bayasula, Nakanishi N, Kasahara Y, et al. Involvement of Transcription Factor 21 in the Pathogenesis of Fibrosis in Endometriosis. Am J Pathol. 2020;190(1):145-57. Epub 2019/10/11. doi: 10.1016/j.ajpath.2019.09.008. PubMed PMID: 31610174.

7.           Viganò P, Ottolina J, Bartiromo L, Bonavina G, Schimberni M, Villanacci R, et al. Cellular Components Contributing to Fibrosis in Endometriosis: A Literature Review. J Minim Invasive Gynecol. 2020;27(2):287-95. Epub 2019/11/27. doi: 10.1016/j.jmig.2019.11.011. PubMed PMID: 31785417.

8.           Hirakawa T, Nasu K, Miyabe S, Kouji H, Katoh A, Uemura N, et al. ?-catenin signaling inhibitors ICG-001 and C-82 improve fibrosis in preclinical models of endometriosis. Sci Rep. 2019;9(1):20056. Epub 2019/12/27. doi: 10.1038/s41598-019-56302-4. PubMed PMID: 31882904; PubMed Central PMCID: PMCPMC6934788.

9.           Meng Q, Sun W, Jiang J, Fletcher NM, Diamond MP, Saed GM. Identification of common mechanisms between endometriosis and ovarian cancer. J Assist Reprod Genet. 2011;28(10):917-23. Epub 2011/05/26. doi: 10.1007/s10815-011-9573-1. PubMed PMID: 21614520; PubMed Central PMCID: PMCPMC3220443.

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