TTX 334Dx Endometriosis Diagnostic


Mission: Improve the quality of life for #1in10 reproductive aged women with endometriosis

Photo by Denys Nevozhai


Goal: Develop a non-invasive, accurate and reliable diagnostic for endometriosis

Problem:  Lack of reliable non-invasive diagnostic method to accurately diagnose endometriosis leads to years of emotional and physical suffering and reduced quality of life.

How: Harness the pro-fibrotic nature of endometriosis and oxidative stress biomarkers to advance precision medicine for diagnosis and ultimately treatment for endometriosis. A collaboration and co-development project with EndoDiag

Disease Background

Endometriosis affects 6-11% of premenopausal women, causing pain, infertility, reduced quality of life and billions of $70 Billion in 2016 (GlobalData 2018) in health care related costs annually. Currently laparoscopic surgery is the only means for providing a definitive diagnosis of endometriosis and most patients struggle to find an effective treatment modality to relieve symptoms. While numerous studies have investigated non-invasive biomarkers for diagnosing endometriosis and predict prognosis and appropriate treatment, none have shown sufficient performance to be translated into clinical use.

What does this mean in context?

  • At present accurate diagnosis is invasive-laparoscopic surgery
  • Endometriosis is the number 1 cause of infertility in the US
  • Prolonged diagnosis cycles rob women of valuable child-bearing years
  • A woman with a sister or mother with endometriosis is six times more likely to develop endometriosis than a woman without this family history
  • Over 400,000 hysterectomies are attributed to advanced stage endometriosis

Work Cited


1.           Simoens S, Dunselman G, Dirksen C, Hummelshoj L, Bokor A, Brandes I, et al. The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres. Hum Reprod. 2012;27(5):1292-9. Epub 2012/03/14. doi: 10.1093/humrep/des073. PubMed PMID: 22422778.

2.           Burghaus S, Klingsiek P, Fasching PA, Engel A, Häberle L, Strissel PL, et al. Risk Factors for Endometriosis in a German Case-Control Study. Geburtshilfe Frauenheilkd. 2011;71(12):1073-9. doi: 10.1055/s-0031-1280436. PubMed PMID: 25253901; PubMed Central PMCID: PMCPMC4166917.

3.           Burghaus S, Häberle L, Schrauder MG, Heusinger K, Thiel FC, Hein A, et al. Endometriosis as a risk factor for ovarian or endometrial cancer - results of a hospital-based case-control study. BMC Cancer. 2015;15:751. Epub 2015/10/21. doi: 10.1186/s12885-015-1821-9. PubMed PMID: 26487094; PubMed Central PMCID: PMCPMC4618513.

4.           Nnoaham KE, Webster P, Kumbang J, Kennedy SH, Zondervan KT. Is early age at menarche a risk factor for endometriosis? A systematic review and meta-analysis of case-control studies. Fertil Steril. 2012;98(3):702-12.e6. Epub 2012/06/22. doi: 10.1016/j.fertnstert.2012.05.035. PubMed PMID: 22728052; PubMed Central PMCID: PMCPMC3502866.

5.           Alpay Z, Saed GM, Diamond MP. Female infertility and free radicals: potential role in adhesions and endometriosis. J Soc Gynecol Investig. 2006;13(6):390-8. Epub 2006/07/26. doi: 10.1016/j.jsgi.2006.05.002. PubMed PMID: 16872846.

6.           Ganieva U, Nakamura T, Osuka S, Bayasula, Nakanishi N, Kasahara Y, et al. Involvement of Transcription Factor 21 in the Pathogenesis of Fibrosis in Endometriosis. Am J Pathol. 2020;190(1):145-57. Epub 2019/10/11. doi: 10.1016/j.ajpath.2019.09.008. PubMed PMID: 31610174.

7.           Viganò P, Ottolina J, Bartiromo L, Bonavina G, Schimberni M, Villanacci R, et al. Cellular Components Contributing to Fibrosis in Endometriosis: A Literature Review. J Minim Invasive Gynecol. 2020;27(2):287-95. Epub 2019/11/27. doi: 10.1016/j.jmig.2019.11.011. PubMed PMID: 31785417.

8.           Hirakawa T, Nasu K, Miyabe S, Kouji H, Katoh A, Uemura N, et al. ?-catenin signaling inhibitors ICG-001 and C-82 improve fibrosis in preclinical models of endometriosis. Sci Rep. 2019;9(1):20056. Epub 2019/12/27. doi: 10.1038/s41598-019-56302-4. PubMed PMID: 31882904; PubMed Central PMCID: PMCPMC6934788.

9.           Meng Q, Sun W, Jiang J, Fletcher NM, Diamond MP, Saed GM. Identification of common mechanisms between endometriosis and ovarian cancer. J Assist Reprod Genet. 2011;28(10):917-23. Epub 2011/05/26. doi: 10.1007/s10815-011-9573-1. PubMed PMID: 21614520; PubMed Central PMCID: PMCPMC3220443.

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