TTX-330 Spinal

 

TTX-330 is a drug and bioresorbable polymer combination that helps reduce peridural fibrosis following spinal surgery. TTX-330 has gone through extensive preclinical experiments in vivo. In rat laminectomy models, TTX-330 showed a clinically relevant statistical significant reduction according to spine surgeons. 

Spinal Surgery Facts

If 10 percent of the patients who have an initial laminectomy operation require a subsequent operation the effect of the post-operative scar tissue on that percentage of patients is significant.

Failure rates for spinal surgery have not changed in the past several decades.

Spinal surgery rates have increased in that time over 5 times. (Chin-wern Chan, 2011)

  • Lumbar laminectomy surgery  most common operation in the United States
  • 3 million procedures performed worldwide with over one third in the US;
  • Direct cost in the USA of low back pain estimiated between 12.2 and 90.6 billion U.S. dollars annually
  • Fourth most expensive condition for employers in the United States.
  • In the United States, back problems were one of the top ten most expensive medical conditions treated in 2005, accounting for $32 billion for visits to doctors’ offices, clinics, emergency departments, hospital stays, home health care, and prescription medicines (Agency for Healthcare Research and Quality, 2008). (Nagy Mekhail, 2011)
  •  Among other chronic pain conditions, the indirect costs of back pain were estimated to be 19.8 billion U.S. dollars, higher than arthritis and other pain conditions (Chin-wern Chan, 2011)

Growth rates for spine surgery are fueled by ageing population, obesity, rising awareness and increasing incomes in developing markets. Asia-Pacific will see a 9% CAGR. 

Despite advances in technology and surgical techniques, the rates of FBSS are similar to several decades ago. (Chin-wern Chan, 2011)

Works Cited

Chin-wern Chan, P. P. (2011). Failed Back Surgery Syndrome Review Article. Pain Medicine , 577-606.

Mark C. Preul, P. K. (2010). Application of a new hydrogel dural sealant that reduces epidural adhesion formation: evaluation in a large animal laminectomy model. Journal of Neurosurgery Spine , 281-390.

Nagy Mekhail, D. L. (2011). Counting the Costs:Case Management Implications of Spinal Cord Stimulation Treatment for Failed Back Surgery Syndrome. Professional Case Management , 27-36

 

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