TTX 330 Orthopedics 

 

TTX-330 (Orthopedics) is a molecule (approved for human use) and bioresorbable polymer (approved for human use) combination that helps reduce fibrosis following surgery or non surgical trauma or inflammation to synovial joints. TTX-330 has gone through extensive preclinical experiments in-vivo. TTX-330 efficacy was tested in the most challenging rat laminectomy models. Here TTX-330 showed a clinically relevant statistical significant reduction in epidural fibrosis according to spine surgeons and a statistically significant drop in TGFb1 markers. This is a key marker found in arthofibrosis. TTX-330 first clinical indication is frozen shoulder (adhesive capsulitis) followed by knee surgeries, such as ACL repair, where scar tissue is an impediment to rehabilitation, movement and pain. 

Arthrofibrosis Facts

Arthofibrosis describes a pathological process in which the body forms excessive scar tissue or adhesions across synovial joints, such as the glenohumeral, knee joint, lower back, ankle and hips, leading to stiffness, pain and dysfunction.

Adhesive Capsulitis of Shoulder Joint (Frozen Shoulder)-estimated that 70% of cases are women.

  • Risk factors: Diabetes, cerebrovascular disease, autoimmune disease, and thyroid disease
  • Inflammatory process which leads to fibrosis or adhesions in the joint
  • Current therapies include corticosteroid (oral and intra-articular injections), physical therapy and surgery

Unmet medical need: No universal effective therapy and future research should target the inflammatory and/or fibrotic pathways.

 

Works Cited

1.           Fitzpatrick J, Richardson C, Klaber I, Richardson MD. (AA4500) for the Treatment of Adhesive Capsulitis of the Shoulder: A Randomised Double-Blind, Placebo-Controlled Study for the Safety and Efficacy of Collagenase - Single Site Report. Drug Des Devel Ther. 2020;14:2707-2713. doi:10.2147/DDDT.S259228

2.           Zreik NH, Malik RA, Charalambous CP. Adhesive capsulitis of the shoulder and diabetes: a meta-analysis of prevalence. Muscles Ligaments Tendons J. 2016 Jan-Mar 2016;6(1):26-34. doi:10.11138/mltj/2016.6.1.026

3.           Page RS, McGee SL, Eng K, et al. Adhesive capsulitis of the shoulder: protocol for the adhesive capsulitis biomarker (AdCaB) study. BMC Musculoskelet Disord. Apr 2019;20(1):145. doi:10.1186/s12891-019-2536-x

4.           Le HV, Lee SJ, Nazarian A, Rodriguez EK. Adhesive capsulitis of the shoulder: review of pathophysiology and current clinical treatments. Shoulder Elbow. Apr 2017;9(2):75-84. doi:10.1177/1758573216676786

5.           Kitridis D, Tsikopoulos K, Bisbinas I, Papaioannidou P, Givissis P. Efficacy of Pharmacological Therapies for Adhesive Capsulitis of the Shoulder: A Systematic Review and Network Meta-analysis. Am J Sports Med. 12 2019;47(14):3552-3560. doi:10.1177/0363546518823337

6.           Redler LH, Dennis ER. Treatment of Adhesive Capsulitis of the Shoulder. J Am Acad Orthop Surg. Jun 2019;27(12):e544-e554. doi:10.5435/JAAOS-D-17-00606

7.           Yip M, Francis AM, Roberts T, Rokito A, Zuckerman JD, Virk MS. Treatment of Adhesive Capsulitis of the Shoulder: A Critical Analysis Review. JBJS Rev. Jun 2018;6(6):e5. doi:10.2106/JBJS.RVW.17.00165

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